Therapeutic Effects of Low-Intensity Pulsed Ultrasound on Premature Ovarian Insufficiency

We explored the therapeutic effects of low-intensity pulsed ultrasound (LIPUS) on a rat model ovarian damage induced by cyclophosphamide. A total 44 female rats with premature insufficiency cyclophosphamide were randomly divided into two groups (an group and control group); 22 normal without also included as third group. The was treated LIPUS, while other received same treatment but any power output. monitored estrous cycles all rats. Seven days after treatment, 21 selected to mate male then recorded pregnancy rate along number weight newborn per nest. collected samples blood, uterus ovaries from remaining 45 before they sacrificed. Compared group, exhibited disordered cycles, more atretic follicles (p < 0.01), higher levels serum follicle-stimulating hormone fewer 0.01) lower E2 anti-Müllerian 0.01). had No significant difference in noted between differences observed three respect or newborns nest > 0.05). In conclusion, our data indicate that LIPUS could improve some functions insufficiency.